Lgi4 Gene Summary [Rat]
Predicted to be involved in myelination in peripheral nervous system; neuron maturation; and regulation of myelination. Predicted to act upstream of or within adult locomotory behavior; gliogenesis; and myelination. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-1 and childhood absence epilepsy. Orthologous to human LGI4 (leucine rich repeat LGI family member 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lgi4 |
| Official Name | leucine-rich repeat LGI family, member 4 [Source:RGD Symbol;Acc:735035] |
| Ensembl ID | ENSRNOG00000021087 |
| Bio databases IDs | |
| Aliases | leucine-rich repeat LGI family, member 4 |
| Synonyms | AMC1, AMCNMY, clp, leucine rich repeat LGI family member 4, leucine-rich repeat LGI family, member 4, LGIL3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lgi4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- protein binding
- Leucine Rich repeats (2 copies)
- EPTP domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- neurogenic arthrogryposis multiplex congenita with myelin defect
- hereditary disorder
- Hodgkin lymphoma
- Hodgkin disease
- epithelial uterine cancer
- androgenic alopecia
- neurogenic arthrogryposis multiplex congenita
- Huntington disease
- cervical small cell carcinoma
role in cell
- proliferation
- development
- maturation
- myelination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lgi4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- myelination in peripheral nervous system
- neuron maturation
- regulation of myelination
- adult locomotory behavior
- glial cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region