Mapk8 Gene Summary [Rat]
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | Mapk8 |
| Official Name | mitogen-activated protein kinase 8 [Source:RGD Symbol;Acc:621506] |
| Ensembl ID | ENSRNOG00000020155 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 8 |
| Synonyms | C-JUN N-TERMINAL KINASE1, JNK, JNK1, JNK1A2, JNK21B1/2, JNK-46, mitogen-activated protein kinase 8, p46JNK1, p46JNK1 alpha, p46JNK1 α, PRKM8, SAPK1, SAPK1c, Sapk gamma, SAPK P46, Sapk γ, STRESS-ACTIVATED protein KINASE-LIKE KINASE |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mapk8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone deacetylase regulator
- glycine rich domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein threonine/tyrosine kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- protein phosphatase binding
- enzyme binding
- histone deacetylase binding
- protein binding
- alpha domain
- Protein kinase domain
- kinesin binding
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- JUN kinase
- alcohol group acceptor phosphotransferase
- substrate binding domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Mapk8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Apelin Liver Signaling Pathway
- Apelin Pancreas Signaling Pathway
- April Mediated Signaling
- Aryl Hydrocarbon Receptor Signaling
- B Cell Activating Factor Signaling
- CXCR4 Signaling
- FGF Signaling
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Gastric Cells
- IL-2 Signaling
- IL-22 Signaling
- Induction of Apoptosis by HIV1
- Inhibition of Angiogenesis by TSP1
- LPS-stimulated MAPK Signaling
- NF-κB Signaling
- PAK Signaling
- Parkinson's Signaling
- PCP pathway
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of MAPK Signaling in the Pathogenesis of Influenza
- STAT3 Pathway
- TNFR1 Signaling
- Toll-like Receptor Signaling
- UVB-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial neoplasia
- epithelial cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- neoplasia
- choroidal neovascularization
- non-insulin-dependent diabetes mellitus
role in cell
- binding in
- rearrangement
- quantity
- contact growth inhibition
- expression in
- apoptosis
- phosphorylation in
- interaction in
- activation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- perinuclear region
- focal adhesions
- podosomes
- Nucleus
- Plasma Membrane
- vesicles
- Mitochondria
- cytosol
- membrane ruffles
- mitochondrial membrane
- nucleoplasm
- neurites
- synapse
- Z line
- perikaryon
- axons
- dendrites
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mapk8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cyclase activity
- cellular response to amino acid starvation
- cellular senescence
- Fc-epsilon receptor signaling pathway
- JNK cascade
- response to UV
- regulation of circadian rhythm
- protein phosphorylation
- negative regulation of protein binding
- JUN phosphorylation
- response to mechanical stimulus
- positive regulation of protein metabolic process
- response to oxidative stress
- cellular response to cadmium ion
- energy homeostasis
- stress-activated MAPK cascade
- regulation of protein localization
- positive regulation of NLRP3 inflammasome complex assembly
- cellular response to mechanical stimulus
- rhythmic process
- cellular response to lipopolysaccharide
- positive regulation of gene expression
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- regulation of macroautophagy
- positive regulation of cell killing
- cellular response to oxidative stress
- peptidyl-serine phosphorylation
- cellular response to reactive oxygen species
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- synapse
- axon
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone deacetylase regulator activity
- ATP binding
- protein binding
- protein phosphatase binding
- histone deacetylase binding
- JUN kinase activity
- protein serine/threonine kinase activity
- enzyme binding