Brinp3 Gene Summary [Rat]
Involved in negative regulation of cell cycle and nervous system development. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human BRINP3 (BMP/retinoic acid inducible neural specific 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brinp3 |
| Official Name | BMP/retinoic acid inducible neural specific 3 [Source:RGD Symbol;Acc:708421] |
| Ensembl ID | ENSRNOG00000002811 |
| Bio databases IDs | |
| Aliases | BMP/retinoic acid inducible neural specific 3 |
| Synonyms | B830045N13Rik, BMP/retinoic acid inducible neural specific 3, bone morphogenetic protein/retinoic acid inducible neural specific 3, DBCCR1L, DBCCR1L1, FAM5C |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Brinp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BMP/retinoic acid-inducible neural-specific protein
- membrane-attack complex / perforin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- adenoma formation
- gout
- Huntington disease
- obesity
- head and neck neuroendocrine neoplasia
- insomnia
- gonadotrophinoma
- overnutrition
role in cell
- proliferation
- migration
- differentiation
- cell cycle progression
- invasion
- mitosis
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Brinp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to retinoic acid
- nervous system development
- positive regulation of neuron differentiation
- negative regulation of mitotic cell cycle
- central nervous system neuron differentiation
Cellular Component
Where in the cell the gene product is active
- dendrite
- cytoplasm
- mitochondrion
- neuronal cell body
- extracellular region