Stim1 Gene Summary [Rat]
Enables calcium channel regulator activity and store-operated calcium channel activity. Involved in activation of store-operated calcium channel activity; regulation of store-operated calcium entry; and store-operated calcium entry. Located in growth cone. Used to study nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stim1 |
| Official Name | stromal interaction molecule 1 [Source:RGD Symbol;Acc:1306831] |
| Ensembl ID | ENSRNOG00000020425 |
| Bio databases IDs | |
| Aliases | stromal interaction molecule 1 |
| Synonyms | D11S4896E, GOK, IMD10, SIM, STRMK, stromal interaction molecule 1, TAM, TAM1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stim1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- PKC phosphorylation site
- F-type ATP synthase, membrane subunit b
- coiled-coil domain
- identical protein binding
- proline rich domain
- ion channel
- Sterile alpha motif
- STIM1 Orai1-activating region
- SAM domain (Sterile alpha motif)
- Acidic casein kinase ii consensus phosphorylation site
- channel regulator
- PspA/IM30 family
- Ezrin/radixin/moesin, alpha-helical domain
- protease binding
- channel activation domain
- SAM (Sterile alpha motif )
- calcium ion binding
- store-operated calcium channel
- protein binding
- basic helix loop helix/Per Arnt Sim domain
- calcium channel regulator
- EF hand like domain
- PEST domain
- serine threonine rich domain
- microtubule plus-end binding
Pathways
Biological processes and signaling networks where the Stim1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- obesity
- atrial fibrillation
- attention deficit hyperactivity disorder
- idiopathic pulmonary fibrosis
- tubular aggregate myopathy type 1
- urticaria
- colorectal cancer
- preeclampsia
role in cell
- growth
- cell viability
- apoptosis
- signaling in
- expression in
- activation in
- phosphorylation in
- proliferation
- binding in
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cortical endoplasmic reticulum
- endoplasmic reticulum mitochondria contact site
- endoplasmic reticulum-plasma membrane junction
- Cytoplasm
- cell surface
- cellular membrane
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- dense granule
- growth cone
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stim1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of calcium ion
- store-operated calcium entry
- enamel mineralization
- positive regulation of adenylate cyclase activity
- regulation of calcium ion transport
- regulation of store-operated calcium entry
- positive regulation of angiogenesis
- cellular calcium ion homeostasis
- activation of store-operated calcium channel activity
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- cortical endoplasmic reticulum
- plasma membrane
- microtubule
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- calcium ion binding
- microtubule plus-end binding
- protease binding
- calcium channel regulator activity