F3 Gene Summary [Rat]
Enables protease binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of smooth muscle cell migration; and response to estradiol. Located in cell surface and extracellular space. Biomarker of disseminated intravascular coagulation; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | F3 |
| Official Name | coagulation factor III, tissue factor [Source:RGD Symbol;Acc:2587] |
| Ensembl ID | ENSRNOG00000011800 |
| Bio databases IDs | |
| Aliases | coagulation factor III, tissue factor |
| Synonyms | AA409063, CD142, Cf-3, coagulation factor III, coagulation factor III, tissue factor, TF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat F3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- phospholipid binding
- serine endopeptidase
- protease binding
- cytoplasmic domain
- transmembrane domain
- intracellular domain
- leucine zipper domain
- protein binding
- Interferon-alpha/beta receptor, fibronectin type III
- Tissue factor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the F3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- diabetic nephropathy
- neoplasia
- sickle cell anemia
- acute lymphoblastic leukemia
- metastasis
- metastatic cervical squamous cell carcinoma
- cervical adenosquamous carcinoma
role in cell
- expression in
- cell death
- killing
- phosphorylation in
- quantity
- activation in
- proliferation
- formation
- apoptosis
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular compartment
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- intercellular junctions
- granules
- granule membrane
- plasma membrane extracellular face
- caveolar membranes
- caveolae
- alpha granule membranes
- secretory granules
- extracellular matrix
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat F3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of positive chemotaxis
- blood coagulation
- activation of plasma proteins involved in acute inflammatory response
- positive regulation of angiogenesis
- activation of blood coagulation via clotting cascade
- positive regulation of interleukin-8 production
- cytokine-mediated signaling pathway
- positive regulation of gene expression
- protein processing
- positive regulation of endothelial cell proliferation
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of TOR signaling cascade
- positive regulation of cell migration
- positive regulation of platelet-derived growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- external side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- protease binding
- phospholipid binding
- cytokine receptor activity