Tuba4a Gene Summary [Rat]
Predicted to enable GTP binding activity and protein kinase binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to be located in cilium and microtubule cytoskeleton. Predicted to be active in cytoplasm and microtubule. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 22. Orthologous to human TUBA4A (tubulin alpha 4a). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tuba4a |
| Official Name | tubulin, alpha 4A [Source:RGD Symbol;Acc:1359623] |
| Ensembl ID | ENSRNOG00000003597 |
| Bio databases IDs | |
| Aliases | tubulin, alpha 4A |
| Synonyms | Alpha tubulin, Alpha-tubulin 1, ALS22, FLJ30169, H2-ALPHA, H2-α, TUBA1, Tuba4, Tubulin alpha 4, tubulin alpha 4a, tubulin, alpha 4A, Tubulin α 4, tubulin α 4a, tubulin, α 4A, α tubulin, α-tubulin 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tuba4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tubulin protein family of FtsZ and CetZ-like
- Tubulin C-terminal domain
- protein kinase binding
- Tubulin/FtsZ family, GTPase domain
- enzyme binding
- protein binding
- Tubulin/FtsZ family, C-terminal domain
Pathways
Biological processes and signaling networks where the Tuba4a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- colorectal cancer
- bleeding
- cancer
- knee osteoarthritis
- non-squamous non-small cell lung cancer
- advanced non-small cell lung adenocarcinoma
- advanced large cell lung carcinoma
- metastatic non-squamous non-small cell lung cancer
- metastatic large cell lung carcinoma
regulates
role in cell
- destabilization
- destabilization in
- repolymerization
- repolymerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cytoskeleton
- cilia
- Extracellular Space
- Nucleus
- microtubules
- cytosol
- membrane rafts
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tuba4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule cytoskeleton organization
- mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- extracellular vesicular exosome
- cytoskeleton
- cytoplasm
- cytosol
- extracellular region
- microtubule
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- metal ion binding
- structural constituent of cytoskeleton
- hydrolase activity