Ptger4 Gene Summary [Rat]
Enables prostaglandin E receptor activity. Involved in several processes, including intracellular signaling cassette; regulation of cytokine production; and regulation of secretion. Located in neuron projection terminus; neuronal cell body; and nuclear membrane. Used to study acute kidney failure; cystitis; end stage renal disease; myocarditis; and osteoporosis. Biomarker of retinal ischemia and transient cerebral ischemia. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptger4 |
| Official Name | prostaglandin E receptor 4 [Source:RGD Symbol;Acc:628641] |
| Ensembl ID | ENSRNOG00000013240 |
| Bio databases IDs | |
| Aliases | prostaglandin E receptor 4 |
| Synonyms | EP4, EP4R, prostaglandin E receptor 4, prostaglandin E receptor 4 (subtype EP4), Ptger, Ptgerep4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptger4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- prostaglandin E receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ptger4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- macular degeneration
- experimental autoimmune encephalomyelitis
- neoplasia
- cancer
- squamous cell cancer
- epithelial cancer
- weight gain
- arthritis
- congestion
- osteoarthritis
role in cell
- expression in
- proliferation
- differentiation
- apoptosis
- activation in
- function
- production in
- phosphorylation in
- activation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- primary cilia
- nuclear envelope
- nerve ending
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptger4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- positive regulation of inflammatory response
- regulation of stress fiber assembly
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- JNK cascade
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cellular response to prostaglandin E stimulus
- response to nematode
- bone development
- elevation of cytosolic calcium ion concentration
- response to mechanical stimulus
- ERK1 and ERK2 cascade
- T-helper cell differentiation
- inflammatory response
- cellular response to mechanical stimulus
- immune response
- negative regulation of eosinophil extravasation
- response to lipopolysaccharide
- negative regulation of cytokine production
- regulation of ossification
- positive regulation of cytokine production
- negative regulation of integrin activation
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- prostaglandin E receptor activity