Ren Gene Summary [Rat]
Enables endopeptidase activity and insulin-like growth factor receptor binding activity. Involved in several processes, including angiotensin maturation; response to cGMP; and response to lipopolysaccharide. Located in extracellular space. Used to study hypertension. Biomarker of hypertension; metabolic dysfunction and alcohol associated liver disease; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in autosomal dominant tubulointerstitial kidney disease; essential hypertension; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ren |
| Official Name | renin [Source:RGD Symbol;Acc:3554] |
| Ensembl ID | ENSRNOG00000002937 |
| Bio databases IDs | |
| Aliases | renin |
| Synonyms | ADTKD4, HNFJ2, Prorenin, RATRENAA, Ren1, Ren1d, Ren-A, RENAA, Renin, renin 1 structural, renin precursor, Rn-1, Rnr, RTD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ren often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Xylanase inhibitor N-terminal
- peptidase
- renin activity
- protein binding
- receptor binding
- Cellular and retroviral pepsin-like aspartate proteases
- handle region
- insulin-like growth factor receptor binding
- A1 Propeptide
- endopeptidase
- aspartic endopeptidase
- Xylanase inhibitor C-terminal
- Eukaryotic aspartyl protease
Pathways
Biological processes and signaling networks where the Ren gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- fibrosis
- edema
- hypertension
- atherosclerosis
- cardiovascular disorder
role in cell
- proliferation
- transcription in
- cellular infiltration by
- binding
- activation
- quantity
- hypertrophy
- damage
- abnormal morphology
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- crinophagic vacuole
- Cytoplasm
- intracellular space
- apical compartment
- cellular membrane
- Plasma Membrane
- vesicles
- granules
- cytoplasmic aggregates
- vesicle membrane
- nerve ending
- secretory granules
- immature secretory granules
- mature secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ren gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- drinking behavior
- regulation of MAPK cascade
- male gonad development
- response to cAMP
- cell maturation
- juxtaglomerular apparatus development
- regulation of blood pressure
- angiotensin maturation
- hormone-mediated signaling pathway
- renin-angiotensin regulation of aldosterone production
- kidney development
- mesonephros development
- proteolysis
- response to lipopolysaccharide
- cellular response to xenobiotic stimulus
- response to immobilization stress
- beta-amyloid metabolic process
- response to cGMP
Cellular Component
Where in the cell the gene product is active
- extracellular space
- apical part of cell
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- aspartic-type endopeptidase activity
- protein binding
- peptidase activity
- receptor binding
- insulin-like growth factor receptor binding