Abcc3 Gene Summary [Rat]
Enables ABC-type bile acid transporter activity. Involved in several processes, including bile acid and bile salt transport; response to estradiol; and response to tetrachloromethane. Acts upstream of or within canalicular bile acid transport. Located in basolateral plasma membrane. Biomarker of bilirubin metabolic disorder (multiple); cholestasis; hyperprolactinemia; kidney disease (multiple); and liver disease (multiple). Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Abcc3 |
| Official Name | ATP binding cassette subfamily C member 3 [Source:RGD Symbol;Acc:71101] |
| Ensembl ID | ENSRNOG00000002948 |
| Bio databases IDs | |
| Aliases | ATP binding cassette subfamily C member 3 |
| Synonyms | 1700019L09Rik, ABC31, ATP-binding cassette C3, ATP binding cassette subfamily C member 3, ATP-binding cassette, sub-family C member 3, cMOAT2, EST90757, MLP2, MOAT-D, MRP3, Multidrug Resistant Protein 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Abcc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein
- phosphonate ABC transporter, ATP-binding protein
- conjugate transporter
- nitrate transport ATP-binding subunits C and D
- heme ABC exporter, ATP-binding protein CcmA
- thiol reductant ABC exporter, CydC subunit
- energy-coupling factor transporter ATPase
- xenobiotic-transporting ATPase
- multi drug resistance-associated protein (MRP)
- thiamine ABC transporter, ATP-binding protein
- bile acid porter
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- ATPase activity, coupled to transmembrane movement of substances
- lipid A export permease/ATP-binding protein MsbA
- inorganic anion transporter
- ABC transporter transmembrane region
- lipid transporter
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- cystic fibrosis transmembrane conductor regulator (CFTR)
- xenobiotic transporter
- NHLM bacteriocin system ABC transporter, ATP-binding protein
- ABC transporter
- transporter
- glucuronoside transporter
Pathways
Biological processes and signaling networks where the Abcc3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- hyperbilirubinemia
- Philadelphia-positive chronic myeloid leukemia
- primary biliary cirrhosis
- lung adenocarcinoma formation
- insulin resistance
- renal clear cell adenocarcinoma
- renal clear cell cancer
- obstructive cholestasis
- streptozotocin induced type1 diabetes
regulates
- anionic conjugate
- morphine-6-glucuronide
- 5(6)-carboxy-2',7'-dichlorofluorescein
- 17beta-estradiol-17-beta-D-glucuronide
- etoposide glucuronide
- bilirubin
- taurocholic acid
- 15-deoxy-delta-12,14 -PGJ 2
- bile salt
- etoposide
role in cell
- cell death
- survival
- cytostasis
- oncogene-induced senescence
- drug resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- cellular membrane
- basal bodies
- vesicles
- basolateral cell surfaces
- basolateral membrane
- basal membrane
- lateral plasma membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Abcc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene transport
- drug transmembrane transport
- transmembrane transport
- xenobiotic metabolic process
- xenobiotic transport
- glucuronoside transport
- bile acid and bile salt transport
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- membrane
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- xenobiotic transporter activity
- ATPase activity
- ATP binding
- ATPase activity, coupled to transmembrane movement of substances
- bile acid-exporting ATPase activity
- glutathione S-conjugate-exporting ATPase activity
- glucuronoside transmembrane transporter activity
- xenobiotic-transporting ATPase activity
- icosanoid transmembrane transporter activity
- anion transmembrane-transporting ATPase activity