Mtdh Gene Summary [Rat]
Predicted to enable NF-kappaB binding activity; double-stranded RNA binding activity; and transcription coactivator activity. Involved in bicellular tight junction assembly. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and intercellular canaliculus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MTDH (metadherin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mtdh |
| Official Name | metadherin [Source:RGD Symbol;Acc:620992] |
| Ensembl ID | ENSRNOG00000006870 |
| Bio databases IDs | |
| Aliases | metadherin |
| Synonyms | 2610103J23Rik, 3D3, 3D3/Lyric, AEG-1, D8Bwg1112e, LYRIC, LYRIC/3D3, metadherin, p80 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mtdh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- NF-kappaB binding
- double-stranded RNA binding
- transmembrane domain
- nuclear localization sequence
- transcription factor binding
- protein binding
- Lysine-rich CEACAM1 co-isolated protein family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- metastasis
- psoriasis
- epithelial cancer
- HIV-associated encephalitis
- Huntington disease
- liver neoplasia
- abdominal aortic aneurysm
- immunodeficiency
role in cell
- proliferation
- binding in
- expression in
- survival
- phosphorylation in
- formation in
- apoptosis
- cell death
- growth
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- fibrillar center
- endoplasmic reticulum mitochondria contact site
- perinuclear region
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- Mitochondria
- intercellular junctions
- endoplasmic reticulum membrane
- apical membrane
- nucleoli
- nuclear bodies
- nuclear envelope
- growth cone
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mtdh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of autophagy
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- lipopolysaccharide-mediated signaling pathway
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of angiogenesis
- positive regulation of protein kinase B signaling cascade
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- intercellular canaliculus
- endoplasmic reticulum membrane
- nucleus
- tight junction
- nuclear membrane
- nuclear body
- perinuclear region of cytoplasm
- cytoplasm
- endoplasmic reticulum
- fibrillar center
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- protein binding
- transcription cofactor activity
- RNA binding
- transcription coactivator activity
- double-stranded RNA binding