Optc Gene Summary [Rat]

Predicted to be involved in articular cartilage development; bone development; and collagen fibril organization. Predicted to act upstream of or within negative regulation of angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human OPTC (opticin). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Optc
Official Name
opticin [Source:RGD Symbol;Acc:1304916]
Ensembl ID
ENSRNOG00000003059
Bio databases IDs NCBI: 304802 Ensembl: ENSRNOG00000003059
Aliases opticin
Synonyms OPT, opticin
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Optc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein phosphatase 1 regulatory subunit 42
  • extracellular matrix structural constituent
  • Leucine rich repeat

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • age-related macular degeneration
  • choroidal neovascularization
regulated by
  • VEGF
  • calcitriol
  • zeaxanthin dipalmitate
  • MMP2
  • geldanamycin
  • MMP7
  • HMOX2
role in cell
  • organization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space
  • extracellular matrix

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Optc gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of angiogenesis
  • angiogenesis
  • collagen fibril organization
  • bone development

Cellular Component

Where in the cell the gene product is active
  • extracellular matrix
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • extracellular matrix structural constituent

Gene-Specific Assays for Results You Can Trust

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