H3f3b

Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II core promoter sequence-specific DNA binding activity; and nucleosomal DNA binding activity. Predicted to be a structural constituent of chromatin. Predicted to be involved in nucleosome assembly; oocyte maturation; and positive regulation of cell growth. Predicted to act upstream of or within several processes, including constitutive heterochromatin formation; negative regulation of chromosome condensation; and osteoblast differentiation. Predicted to be located in Barr body; chromosome, telomeric region; and nucleoplasm. Predicted to be part of inner kinetochore and nucleosome. Predicted to be active in chromatin and chromosome, centromeric region. Human ortholog(s) of this gene implicated in Bryant-Li-Bhoj neurodevelopmental syndrome 1. Orthologous to several human genes including H3-3A (H3.3 histone A). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat H3f3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the H3f3b gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat H3f3b gene, providing context for its role in the cell.