Tspan7 Gene Summary [Rat]
Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in postsynapse. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Orthologous to human TSPAN7 (tetraspanin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tspan7 |
| Official Name | tetraspanin 7 [Source:RGD Symbol;Acc:1589725] |
| Ensembl ID | ENSRNOG00000003229 |
| Bio databases IDs | |
| Aliases | tetraspanin 7 |
| Synonyms | 1200014P11Rik, A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, PE31, TALLA, TALLA-1, tetraspanin 7, TM4SF2, TM4SF2b, Tspan-2, XLID58 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tspan7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tetraspanin_LEL
- protein binding
- Tetraspanin family
Pathways
Biological processes and signaling networks where the Tspan7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- breast cancer
- hepatocellular carcinoma
- X-linked mental retardation type 58
- weight gain
- celiac disease
- nonsyndromic X-linked mental retardation
- colorectal adenoma
- colorectal adenoma formation
role in cell
- cell spreading
- shape change
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- postsynaptic region
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tspan7 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding