Oxtr Gene Summary [Rat]
Enables ionotropic glutamate receptor binding activity; oxytocin receptor activity; and peptide hormone binding activity. Involved in several processes, including ERK1 and ERK2 cascade; estrous cycle; and positive regulation of synaptic transmission. Located in adherens junction; apical plasma membrane; and microvillus. Used to study alcohol dependence and gastric ulcer. Biomarker of hypertension. Human ortholog(s) of this gene implicated in alcohol dependence; depressive disorder; impulse control disorder; personality disorder; and substance abuse (multiple). Orthologous to human OXTR (oxytocin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oxtr |
| Official Name | oxytocin receptor [Source:RGD Symbol;Acc:3239] |
| Ensembl ID | ENSRNOG00000005806 |
| Bio databases IDs | |
| Aliases | oxytocin receptor |
| Synonyms | OT-R, OTR1, Oxtr1, oxytocin receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Oxtr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- oxytocin receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- ionotropic glutamate receptor binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
Pathways
Biological processes and signaling networks where the Oxtr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- epithelial neoplasia
- neoplasia
- obesity
- postpartum hemorrhage
- schizoaffective disorder
- premenstrual dysphoric disorder
- schizophrenia
- vaginal atrophy
role in cell
- binding
- expression in
- proliferation
- phosphorylation in
- translation in
- growth
- elevation in
- tyrosine phosphorylation in
- recruitment in
- late long term potentiation phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- Endoplasmic Reticulum
- granules
- basolateral cell surfaces
- apical membrane
- microvilli
- postsynaptic density
- presynaptic terminals
- inhibitory synapse
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Oxtr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- sperm ejaculation
- telencephalon development
- positive regulation of synaptic transmission, GABAergic
- positive regulation of vasoconstriction
- response to progesterone stimulus
- positive regulation of penile erection
- lactation
- response to xenobiotic stimulus
- memory
- regulation of systemic arterial blood pressure by vasopressin
- eating behavior
- maternal behavior
- heart development
- digestive tract development
- muscle contraction
- suckling behavior
- positive regulation of synaptic transmission, glutamatergic
- positive regulation of synapse assembly
- social behavior
- G-protein coupled receptor signaling pathway
- response to cocaine
- female pregnancy
- cell surface receptor signaling pathway
- response to peptide hormone stimulus
- maternal process involved in parturition
- positive regulation of blood pressure
- elevation of cytosolic calcium ion concentration
- ERK1 and ERK2 cascade
- response to amphetamine
- positive regulation of uterine smooth muscle contraction
- response to estradiol stimulus
- response to anoxia
- cellular response to hormone stimulus
- positive regulation of norepinephrine secretion
Cellular Component
Where in the cell the gene product is active
- adherens junction
- microvillus
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- vasopressin receptor activity
- peptide binding
- peptide hormone binding
- oxytocin receptor activity