Irx3 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including His-Purkinje system development; kidney development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within mesoderm development; negative regulation of neuron differentiation; and positive regulation of neuron differentiation. Predicted to be located in axon and cytoplasm. Predicted to be active in nucleus. Orthologous to human IRX3 (iroquois homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Irx3 |
| Official Name | iroquois homeobox 3 [Source:RGD Symbol;Acc:1307424] |
| Ensembl ID | ENSRNOG00000011533 |
| Bio databases IDs | |
| Aliases | iroquois homeobox 3 |
| Synonyms | iroquois homeobox 3, Iroquois related homeobox 3, IRX-1, IRXB1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Irx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- Motif in Iroquois-class homeodomain proteins (only)
- nucleic acid binding
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- epithelial cancer
- weight gain
- renal clear cell adenocarcinoma
- renal clear cell cancer
- prostatic carcinoma
role in cell
- quantity
- expression in
- expansion
- differentiation
- generation
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Irx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- mesoderm development
- negative regulation of neuron differentiation
- His-Purkinje system cell differentiation
- positive regulation of neuron differentiation
- cell development
- cardiac Purkinje fiber development
- positive regulation of transcription from RNA polymerase II promoter
- atrioventricular bundle cell differentiation
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- specification of loop of Henle identity
- metanephros development
- energy homeostasis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- axon
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity