Gprc5b

Predicted to enable protein kinase activator activity; protein kinase inhibitor activity; and protein tyrosine kinase binding activity. Predicted to be involved in several processes, including cell volume homeostasis; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Predicted to act upstream of or within several processes, including glucose homeostasis; positive regulation of neuron projection development; and positive regulation of protein kinase activity. Predicted to be located in cell surface; cytosol; and nuclear lumen. Predicted to be part of receptor complex. Predicted to be active in several cellular components, including extracellular exosome; membrane raft; and plasma membrane. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts. Orthologous to human GPRC5B (G protein-coupled receptor class C group 5 member B). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gprc5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Gprc5b gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Gprc5b gene, providing context for its role in the cell.