Tspan7 Gene Summary [Mouse]

Predicted to be involved in regulation of postsynaptic neurotransmitter receptor internalization. Predicted to be located in membrane and postsynapse. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; gut; peripheral nervous system ganglion; retina; and trigeminal nerve. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Orthologous to human TSPAN7 (tetraspanin 7). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Tspan7
Official Name
tetraspanin 7 [Source:MGI Symbol;Acc:MGI:1298407]
Ensembl ID
ENSMUSG00000058254
Bio databases IDs NCBI: 21912 Ensembl: ENSMUSG00000058254
Aliases tetraspanin 7
Synonyms 1200014P11Rik, A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, PE31, TALLA, TALLA-1, tetraspanin 7, TM4SF2, TM4SF2b, Tspan-2, XLID58
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tspan7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • tetraspanin_LEL
  • protein binding
  • Tetraspanin family

Pathways

Biological processes and signaling networks where the Tspan7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • liver cancer
  • epithelial cancer
  • breast cancer
  • hepatocellular carcinoma
  • X-linked mental retardation type 58
  • weight gain
  • celiac disease
  • nonsyndromic X-linked mental retardation
  • colorectal adenoma
  • colorectal adenoma formation
regulated by
role in cell
  • cell spreading
  • shape change

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cell surface
  • postsynaptic region
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Tspan7 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.