Btg2 Gene Summary [Rat]
Enables transcription corepressor activity. Involved in several processes, including cellular response to phorbol 13-acetate 12-myristate; negative regulation of neuron apoptotic process; and response to electrical stimulus. Acts upstream of or within negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; and neuron differentiation. Predicted to be active in cytoplasm and nucleus. Biomarker of acute necrotizing pancreatitis and brain ischemia. Orthologous to human BTG2 (BTG anti-proliferation factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Btg2 |
| Official Name | BTG anti-proliferation factor 2 [Source:RGD Symbol;Acc:2225] |
| Ensembl ID | ENSRNOG00000003300 |
| Bio databases IDs | |
| Aliases | BTG anti-proliferation factor 2 |
| Synonyms | Agl, An, an-1, APRO1, B-cell translocation gene 2, antiproliferative, BTG anti-proliferation factor 2, circRNA BTG2, Evi38, PC3, TIS21 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Btg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTG family
- transcription regulator
- LXXLL motif
- transcription co-repressor
- protein binding
- BoxC domain
- Box B domain
- BTG2 Box A domain
- tob/btg1 family
Pathways
Biological processes and signaling networks where the Btg2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- epithelial cancer
- breast cancer
- hyperplasia
- proximal tubular toxicity
- squamous-cell carcinoma
- squamous cell cancer
- lymphomagenesis
- B cell cancer
role in cell
- expression in
- phosphorylation in
- proliferation
- development
- apoptosis
- permeability transition
- motility
- cell death
- depolarization
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Btg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- neuron projection development
- negative regulation of cell proliferation
- anterior/posterior pattern specification
- negative regulation of mitotic cell cycle
- response to organic cyclic compound
- central nervous system neuron development
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- associative learning
- response to DNA damage stimulus
- response to peptide hormone stimulus
- dentate gyrus development
- response to mechanical stimulus
- negative regulation of neuron apoptotic process
- negative regulation of transcription from RNA polymerase II promoter
- neuroblast proliferation
- negative regulation of neuroblast proliferation
- skeletal muscle cell differentiation
- response to electrical stimulus
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription corepressor activity