Mmp1 Gene Summary [Rat]
Enables peptidase activity. Involved in several processes, including cellular response to cytokine stimulus; female gonad development; and positive regulation of cell migration. Located in extracellular space. Used to study several diseases, including artery disease (multiple); degenerative disc disease; liver cirrhosis; pulmonary fibrosis; and ulcerative colitis. Biomarker of several diseases, including chronic obstructive pulmonary disease; liver cirrhosis; scoliosis; tendinitis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); intrinsic cardiomyopathy (multiple); obstructive lung disease (multiple); and urinary system cancer (multiple). Orthologous to human MMP1 (matrix metallopeptidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmp1 |
| Official Name | matrix metallopeptidase 1 [Source:RGD Symbol;Acc:1307917] |
| Ensembl ID | ENSRNOG00000032353 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 1 |
| Synonyms | Clgn, matrix metallopeptidase 1, matrix metallopeptidase 1a (interstitial collagenase), Mcol-A, Mmp1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mmp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative peptidoglycan binding domain
- Matrixin
- Hemopexin-like repeats
- ZnMc
- endopeptidase
- peptidase
- HX
- Zinc-dependent metalloprotease
- protein binding
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Mmp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Atherosclerosis Signaling
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HIF1α Signaling
- IL-17A Signaling in Fibroblasts
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Oncostatin M Signaling
- Osteoarthritis Pathway
- RAR Activation
- Role of IL-17A in Arthritis
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CREB
- FOS (family)
- JUN
disease
- neoplasia
- cancer
- lung cancer
- thoracic cancer
- lung carcinoma process
- epithelial cancer
- epithelial neoplasia
- tumorigenesis
phenotypes
- Adult Cerebral Astrocytoma
- Airway Obstruction
- Amaurosis Fugax
- Barrett's esophagus
- Chronic Periodontitis
- Colorectal Neoplasms
- Congenital Nephrotic Syndrome with or without Ocular Abnormalities
- Coronary Disease
- Diabetes Mellitus Experimental
- Dissecting Aneurysm
- Emphysema
- Experimental Arthritis
- Experimental Autoimmune Uveitis
- Fetal Hypoxia
- HIV-Associated Lipodystrophy Syndrome
- Head and Neck Neoplasms
- Hearing Loss Sudden
- Hyperplasia
- Immunoglobulin Light-chain Amyloidosis
- Kidney Neoplasms
- Knee Osteoarthritis
- Lung Neoplasms
- Mammary Neoplasms Experimental
- Multiple Organ Failure
- Myocardial Reperfusion Injury
- Nasal Polyps
- Polymyositis
- Sepsis
- Stroke
- Subarachnoid Hemorrhage
- abdominal aortic aneurysm
- amyotrophic lateral sclerosis
- Aortic Valve Stenosis
- Arteriosclerosis
- Atherosclerosis
- Atrial Fibrillation
- autosomal dominant polycystic kidney disease
- breast cancer
- carotid artery disease
- Carotid Stenosis
- cervical cancer
- cholesteatoma of middle ear
- chronic obstructive pulmonary disease
- congestive heart failure
- Coronary Artery Disease
- degenerative disc disease
- dermatomyositis
- dilated cardiomyopathy
- end stage renal failure
- esophagus adenocarcinoma
- Exfoliation Syndrome
- glomerulosclerosis
- hypertension
- hypertrophic cardiomyopathy
- Idiopathic Pulmonary Fibrosis
- intermediate coronary syndrome
- Liver Cirrhosis
- localized scleroderma
- lung cancer
- Myocardial Infarction
- obstructive lung disease
- Ocular Hypertension
- Osteoarthritis
- ovarian cancer
- Periodontitis
- primary open angle glaucoma
- psoriatic arthritis
- Pulmonary Emphysema
- Pulmonary Fibrosis
- pulmonary hypertension
- renal cell carcinoma
- Renal Fibrosis
- rheumatoid arthritis
- scoliosis
- skin melanoma
- stomach carcinoma
- systemic lupus erythematosus
- systemic scleroderma
- tendinitis
- thoracic aortic aneurysm
- thrombosis
- type 2 diabetes mellitus
- ulcerative colitis
- urinary bladder cancer
- Varicose Veins
- Sudden Hearing Loss
- end stage renal disease
- COVID-19
- Experimental Diabetes Mellitus
role in cell
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space