Cnot7 Gene Summary [Rat]
Predicted to enable several functions, including piRNA binding activity; poly(A)-specific ribonuclease activity; and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of type I interferon-mediated signaling pathway; positive regulation of viral genome replication; and regulation of primary metabolic process. Predicted to act upstream of or within P-body assembly and positive regulation of RNA metabolic process. Predicted to be located in P-body and nuclear speck. Predicted to be part of CCR4-NOT complex. Predicted to be active in intracellular membraneless organelle. Biomarker of male infertility. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnot7 |
| Official Name | CCR4-NOT transcription complex, subunit 7 [Source:RGD Symbol;Acc:1305313] |
| Ensembl ID | ENSRNOG00000012263 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex, subunit 7 |
| Synonyms | CAF-1, Caf1a, CCR4-NOT transcription complex subunit 7, CCR4-NOT transcription complex, subunit 7, hCAF-1, Pop2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cnot7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exoribonuclease
- transcription regulator
- poly(A)-specific ribonuclease
- exoribonuclease
- CAF1 family ribonuclease
- transcription co-repressor
- transcription factor binding
- protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Cnot7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- acute myeloid leukemia
- gastric cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- hypoplasia
- hyperplasia
- oligozoospermia
- infection by Sendai virus
role in cell
- expression in
- translation in
- proliferation
- formation in
- binding in
- replication in
- degradation in
- formation
- number
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- GW body
- cytoplasmic mRNA processing body
- organelle
- Cytoplasm
- cytosol
- nuclear foci
- nuclear bodies
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cnot7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of mRNA catabolic process
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- negative regulation of cell proliferation
- regulation of tyrosine phosphorylation of STAT protein
- positive regulation of cell proliferation
- negative regulation of type I interferon-mediated signaling pathway
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- positive regulation of transcription from RNA polymerase II promoter
- nuclear-transcribed mRNA poly(A) tail shortening
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- regulation of translation
- negative regulation of gene expression
- negative regulation of transcription, DNA-dependent
- deadenylation-dependent decapping of nuclear-transcribed mRNA
- cytoplasmic mRNA processing body assembly
- gene silencing by RNA
- defense response to virus
- positive regulation of viral genome replication
- mRNA cleavage involved in gene silencing by miRNA
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- nuclear speck
- membrane
- cytoplasmic mRNA processing body
- intracellular non-membrane-bounded organelle
- cytosol
- CCR4-NOT core complex
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- 3'-5'-exoribonuclease activity
- protein binding
- RNA binding
- metal ion binding
- transcription corepressor activity
- exoribonuclease activity