Aim2 Gene Summary [Rat]
Predicted to enable several functions, including cysteine-type endopeptidase activator activity; identical protein binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; protein-containing complex assembly; and regulation of DNA-binding transcription factor activity. Predicted to act upstream of or within cellular response to xenobiotic stimulus and positive regulation of interleukin-1 beta production. Predicted to be located in mitochondrion. Predicted to be part of AIM2 inflammasome complex. Predicted to be active in cytosol; nucleoplasm; and site of double-strand break. Orthologous to human AIM2 (absent in melanoma 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aim2 |
| Official Name | absent in melanoma 2 [Source:RGD Symbol;Acc:1307283] |
| Ensembl ID | ENSRNOG00000003480 |
| Bio databases IDs | |
| Aliases | absent in melanoma 2 |
| Synonyms | absent in melanoma 2, Gm1313, Ifi210, LOC105371461, PYHIN4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aim2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PAAD/DAPIN/Pyrin domain
- signaling receptor activity
- double-stranded DNA binding
- protein binding activity, bridging
- protein binding
- enzyme regulator activity
- HIN-200/IF120x domain
- protease activator
- identical protein binding
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Aim2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- proteinuria
- neoplasia
- insulin-dependent diabetes mellitus
- psoriasis
- rheumatoid arthritis
- gastric carcinoma
- gastric epithelial cancer
- gout
- mature T-cell neoplasia
role in cell
- expression in
- activity
- activation in
- migration
- phosphorylation in
- activation
- proliferation
- production in
- cellular infiltration by
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aim2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of NF-kappaB transcription factor activity
- positive regulation of inflammatory response
- positive regulation of defense response to virus by host
- brain development
- response to DNA damage stimulus
- pattern recognition receptor signaling pathway
- positive regulation of NF-kappaB transcription factor activity
- T cell homeostasis
- regulation of behavior
- neuron homeostasis
- inflammatory response
- tumor necrosis factor-mediated signaling pathway
- immune response
- activation of innate immune response
- innate immune response
- pyroptosis
- defense response to virus
- cellular response to xenobiotic stimulus
- positive regulation of cysteine-type endopeptidase activity
- positive regulation of interleukin-1 beta production
- cellular response to interferon-beta
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- site of double-strand break
- cytoplasm
- AIM2 inflammasome complex
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- signaling adaptor activity
- double-stranded DNA binding