Psmc1 Gene Summary [Rat]
Enables TBP-class protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of proteasome regulatory particle, base subcomplex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss. Orthologous to human PSMC1 (proteasome 26S subunit, ATPase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmc1 |
| Official Name | proteasome 26S subunit, ATPase 1 [Source:RGD Symbol;Acc:621097] |
| Ensembl ID | ENSRNOG00000003951 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, ATPase 1 |
| Synonyms | NEDGTH, P26S4, p56, protease (prosome, macropain) 26S subunit, ATPase 1, Proteasome 26s subunit, proteasome 26S subunit, ATPase 1, PRS4, RPT2, Rpt2/S4, S4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Psmc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 26S proteasome subunit P45 family
- Proteasomal ATPase OB C-terminal domain
- AAA ATPase domain
- peptidase
- isomerase
- protein binding
- AAA+ lid domain
- ATPase
- TATA-binding protein binding
- AAA domain
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- HbYX motif
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Psmc1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sickle cell anemia
- neurodegeneration
- androgenic alopecia
- Parkinson disease
- Birk-Aharoni syndrome
role in cell
- expression in
- cell death
- accumulation in
- killing
- growth
- accumulation
- assembly in
- lipotoxicity in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- clastosomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Psmc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- proteasome regulatory particle, base subcomplex
- membrane
- cytosol
- proteasome complex
- proteasome accessory complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding