Gabra1 Gene Summary [Rat]
Enables GABA-A receptor activity; diazepam binding activity; and ligand-gated monoatomic ion channel activity. Contributes to GABA receptor activity. Involved in several processes, including GABAergic synaptic transmission; cellular response to histamine; and response to auditory stimulus. Part of GABA receptor complex. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Biomarker of hepatic encephalopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 19. Orthologous to human GABRA1 (gamma-aminobutyric acid type A receptor subunit alpha1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabra1 |
| Official Name | gamma-aminobutyric acid type A receptor alpha1 subunit [Source:RGD Symbol;Acc:61855] |
| Ensembl ID | ENSRNOG00000003512 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid type A receptor alpha1 subunit |
| Synonyms | DEE19, ECA4, EIEE19, EJM, EJM5, GABAA alpha1, GABAAR-alpha1, GABA A receptor subunit alpha1, gamma-aminobutyric acid type A receptor subunit alpha 1, α-1 gaba A receptor, γ-aminobutyric acid type A receptor subunit alpha1, γ-aminobutyric acid type A receptor subunit α 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gabra1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- extracellular domain
- intracellular loop
- transmembrane helix kinks
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- intracellular M3-M4 domain
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- ion channel
- GABA receptor
- anion channel
- LGIC_ECD
- neurotransmitter receptor
- binding protein
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- transmembrane domain
- ligand-gated ion channel
- intracellular domain
- loop domain
Pathways
Biological processes and signaling networks where the Gabra1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- migraine without aura
- migraine with aura
- migraines
- status epilepticus
- convulsion
- inflammatory bowel disease
- nausea and vomiting
- obesity
- female infertility
role in cell
- expression in
- apoptosis
- activity
- number
- conduction
- abnormal morphology
- assembly
- response by
- transmembrane potential
- miniature inhibitory postsynaptic current in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- synaptic cleft
- cell surface
- intracellular space
- somatodendritic region
- cellular membrane
- Endoplasmic Reticulum
- presynaptic membrane
- synaptic membrane
- dendritic spines
- synaptic components
- synaptic vesicles
- nerve ending
- synaptosomes
- synapse
- perikaryon
- dendrites
- postsynaptic density
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gabra1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- dendrite membrane
- cytoplasmic vesicle membrane
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GABA-A receptor activity
- GABA receptor activity
- chloride channel activity
- benzodiazepine receptor activity
- GABA-gated chloride ion channel activity