Os9 Gene Summary [Rat]
Enables protease binding activity. Involved in protein targeting. Located in endoplasmic reticulum lumen. Orthologous to human OS9 (OS9 endoplasmic reticulum lectin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Os9 |
| Official Name | OS9, endoplasmic reticulum lectin [Source:RGD Symbol;Acc:1359574] |
| Ensembl ID | ENSRNOG00000025570 |
| Bio databases IDs | |
| Aliases | OS9, endoplasmic reticulum lectin |
| Synonyms | 4632413K17RIK, amplified in osteosarcoma, AU022351, ERLEC2, LOC102547508, OS9 endoplasmic reticulum lectin, OS9, endoplasmic reticulum lectin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Os9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- Glucosidase II beta subunit-like protein
- protein binding
- mannose 6-phosphate receptor homology domain
Pathways
Biological processes and signaling networks where the Os9 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- insomnia
- androgenic alopecia
- ulcerative colitis
- multiple sclerosis
role in cell
- expression in
- endoplasmic reticulum-associated degradation in
- downregulation in
- decay in
- retention in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell surface
- perinuclear region
- cellular membrane
- vesicles
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Os9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- endoplasmic reticulum unfolded protein response
- retrograde protein transport, ER to cytosol
- response to endoplasmic reticulum stress
- protein retention in ER lumen
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- Hrd1p ubiquitin ligase complex
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- protease binding
- carbohydrate binding