Qsox1 Gene Summary [Rat]
Enables FAD binding activity and flavin-dependent sulfhydryl oxidase activity. Predicted to be involved in extracellular matrix assembly; negative regulation of macroautophagy; and protein folding. Located in extracellular space. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Qsox1 |
| Official Name | quiescin sulfhydryl oxidase 1 [Source:RGD Symbol;Acc:68957] |
| Ensembl ID | ENSRNOG00000003649 |
| Bio databases IDs | |
| Aliases | quiescin sulfhydryl oxidase 1 |
| Synonyms | 1300003H02Rik, b2b2673Clo, BPGF1, FLJ23867, Q6, QSCN6, QSOX, quiescin Q6 sulfhydryl oxidase 1, quiescin Q6 sulphydryl oxidase 1, quiescin sulfhydryl oxidase 1, quiescin sulphydryl oxidase 1, rSOx, SOx, Sox-2, Sulfhydryl oxidase 1, sulphydryl oxidase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Qsox1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding
- protein disulfide-isomerase
- QSOX Trx-like domain
- Erv1 / Alr family
- flavin-linked sulfhydryl oxidase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endometriosis
- breast cancer
- aortic valve calcification
- anorexia nervosa
- papillary thyroid carcinoma
- papillary thyroid cancer
role in cell
- growth
- assembly
- macroautophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- secretory granule lumen
- Extracellular Space
- organelle lumens
- Golgi Apparatus
- Endoplasmic Reticulum
- cytoplasmic bridges
- endoplasmic reticulum lumen
- Golgi membrane
- alpha granules
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Qsox1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of macroautophagy
- extracellular matrix assembly
- protein folding
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- endoplasmic reticulum lumen
- intercellular bridge
- extracellular space
- extracellular vesicular exosome
- specific granule lumen
- intracellular membrane-bounded organelle
- Golgi apparatus
- Golgi membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- FAD binding
- protein disulfide isomerase activity
- flavin-linked sulfhydryl oxidase activity