Nup85 Gene Summary [Rat]
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nephron development; nucleocytoplasmic transport; and positive regulation of DNA-templated transcription. Predicted to act upstream of or within lamellipodium assembly and macrophage chemotaxis. Predicted to be located in several cellular components, including cytoskeleton; kinetochore; and nucleus. Predicted to be part of nuclear pore outer ring. Human ortholog(s) of this gene implicated in nephrotic syndrome type 17. Orthologous to human NUP85 (nucleoporin 85). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup85 |
| Official Name | nucleoporin 85 [Source:RGD Symbol;Acc:1311942] |
| Ensembl ID | ENSRNOG00000003673 |
| Bio databases IDs | |
| Aliases | nucleoporin 85 |
| Synonyms | FROUNT, NPHS17, nucleoporin 85, Nup75, Pcnt1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nup85 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- Nup85 Nucleoporin
- protein binding
Pathways
Biological processes and signaling networks where the Nup85 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- intracellular membrane-bounded organelle
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- basal bodies
- metaphase plate
- cytosol
- nuclear pores
- nucleoplasm
- nuclear rim
- spindle pole
- nuclear envelope
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nup85 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- nucleocytoplasmic transport
- positive regulation of transcription, DNA-dependent
- macrophage chemotaxis
- protein import into nucleus
- lamellipodium assembly
- nephron development
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- Nup107-160 complex
- nuclear membrane
- membrane
- spindle
- cytosol
- kinetochore
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of nuclear pore