Nup133 Gene Summary [Rat]
Predicted to be a structural constituent of nuclear pore. Predicted to be involved in several processes, including nuclear pore organization; nucleocytoplasmic transport; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to act upstream of or within nervous system development; paraxial mesoderm development; and somite development. Predicted to be located in kinetochore and nuclear membrane. Predicted to be part of nuclear pore outer ring. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Orthologous to human NUP133 (nucleoporin 133). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup133 |
| Official Name | nucleoporin 133 [Source:RGD Symbol;Acc:1307827] |
| Ensembl ID | ENSRNOG00000017919 |
| Bio databases IDs | |
| Aliases | nucleoporin 133 |
| Synonyms | FLJ10814, GAMOS8, hNUP133, mermaid, NPHS18, nucleoporin 133, Nucleoporin Nup133 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nup133 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Non-repetitive/WGA-negative nucleoporin C-terminal
- structural constituent of nuclear pore
- protein binding
Pathways
Biological processes and signaling networks where the Nup133 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- systemic sclerosis
- nephrotic syndrome type 18
- post-traumatic stress disorder
- Galloway-Mowat syndrome type 8
- infection by HIV-1
role in cell
- organization
- association
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nuclear pores
- inner nuclear membrane
- outer nuclear membrane
- spindle pole
- perichromosomal layer
- spindle fibers
- nuclear envelope
- kinetochores
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nup133 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- neural tube development
- nucleocytoplasmic transport
- nuclear pore organization
- somite development
- protein import into nucleus
- paraxial mesoderm development
- neurogenesis
- nephron development
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- Nup107-160 complex
- membrane
- cytosol
- kinetochore
- nuclear pore
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of nuclear pore