Cd274 Gene Summary [Rat]
Predicted to enable receptor ligand activity and transcription coactivator activity. Involved in positive regulation of T cell proliferation and positive regulation of cell migration. Located in cell surface. Biomarker of periodontitis and pre-eclampsia. Orthologous to human CD274 (CD274 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd274 |
| Official Name | CD274 molecule [Source:RGD Symbol;Acc:1566211] |
| Ensembl ID | ENSRNOG00000016112 |
| Bio databases IDs | |
| Aliases | CD274 molecule |
| Synonyms | A530045L16RIK, B7-H, B7H1, CD274 antigen, CD274 molecule, hPD-L1, Pd1l, PDCD1L1, PDCD1LG1, PD-L1, RGD1566211 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd274 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- transcription co-activator
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- receptor agonist activity
- protein binding
- Ig-like V domain
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Cd274 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastatic non-small cell lung cancer
- locally advanced non-small cell lung cancer
- infection
- melanoma cancer
- metastasis
- cancer
- tuberculosis
- rheumatoid arthritis
- plasma cell myeloma
role in cell
- activation
- quantity
- phosphorylation in
- expression in
- colony formation
- invasion by
- migration
- growth
- apoptosis
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- retraction fibers
- actin cytoskeleton
- Endoplasmic Reticulum
- granules
- plasma membrane extracellular face
- endosomal membrane
- nucleoplasm
- recycling endosomes
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd274 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to cytokine stimulus
- negative regulation of CD8-positive, alpha-beta T cell activation
- T cell costimulation
- signal transduction
- negative regulation of interleukin-10 production
- regulation of activated T cell proliferation
- negative regulation of activated T cell proliferation
- adaptive immune response
- cell surface receptor signaling pathway
- positive regulation of T cell proliferation
- negative regulation of T cell mediated immune response to tumor cell
- immune response
- regulation of T cell apoptotic process
- cellular response to lipopolysaccharide
- positive regulation of transcription, DNA-dependent
- negative regulation of T cell proliferation
- positive regulation of interleukin-10 production
- negative regulation of interferon-gamma production
- negative regulation of CD4-positive, alpha-beta T cell proliferation
- TRIF-dependent toll-like receptor signaling pathway
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- nucleus
- extracellular vesicular exosome
- actin cytoskeleton
- external side of plasma membrane
- recycling endosome membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- receptor agonist activity