Ppp4r3b Gene Summary [Rat]
Predicted to enable protein phosphatase activator activity. Predicted to be involved in DNA damage response and regulation of double-strand break repair. Predicted to act upstream of or within positive regulation of gluconeogenesis and protein dephosphorylation. Predicted to be located in several cellular components, including centrosome; chromatin; and nuclear speck. Predicted to be part of protein phosphatase 4 complex. Predicted to be active in nucleoplasm. Orthologous to human PPP4R3B (protein phosphatase 4 regulatory subunit 3B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp4r3b |
| Official Name | protein phosphatase 4, regulatory subunit 3B [Source:RGD Symbol;Acc:1309450] |
| Ensembl ID | ENSRNOG00000003712 |
| Bio databases IDs | |
| Aliases | protein phosphatase 4, regulatory subunit 3B |
| Synonyms | FLFL2, LOC100042972, mKIAA1387, PP4R3B, protein phosphatase 4 regulatory subunit 3B, protein phosphatase 4, regulatory subunit 3B, PSY2, RGD1309450, SMEK2, smk1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp4r3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phosphatase 4 regulatory subunit 3
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hutchinson-Gilford progeria syndrome
- metabolic syndrome X
regulated by
- mir-21 (includes others)
- lenalidomide
- elaidic acid
- WAKMAR1
role in cell
- expression in
- number
- gluconeogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp4r3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gluconeogenesis
- regulation of double-strand break repair
- protein dephosphorylation
- response to DNA damage stimulus
- positive regulation of gluconeogenesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- nuclear speck
- protein phosphatase 4 complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase activator activity