Lfng Gene Summary [Rat]
Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in lymphocyte differentiation; negative regulation of Notch signaling pathway involved in somitogenesis; and somitogenesis. Predicted to act upstream of or within several processes, including compartment pattern specification; positive regulation of Notch signaling pathway; and regulation of somitogenesis. Predicted to be located in Golgi membrane. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 3. Orthologous to human LFNG (LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lfng |
| Official Name | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Source:RGD Symbol;Acc:620587] |
| Ensembl ID | ENSRNOG00000001250 |
| Bio databases IDs | |
| Aliases | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase |
| Synonyms | LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, LFNG O-fucosylpeptide 3-β-N-acetylglucosaminyltransferase, SCDO3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lfng often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylglucosaminyltransferase
- galactosyltransferase
- enzyme
Pathways
Biological processes and signaling networks where the Lfng gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- spondylocostal dysostosis type 3
- Crohn disease
- chronic periodontal disease
- pancreatic cancer
role in cell
- proliferation
- expression in
- generation
- migration
- invasion by
- binding
- differentiation
- quantity
- maturation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lfng gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell differentiation
- marginal zone B cell differentiation
- regulation of somitogenesis
- somitogenesis
- regulation of Notch signaling pathway
- compartment pattern specification
- positive regulation of Notch signaling pathway
- positive regulation of meiotic cell cycle
- ovarian follicle development
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity