Dars Gene Summary [Rat]
This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Details
| Type | Protein Coding |
| Official Symbol | Dars |
| Official Name | aspartyl-tRNA synthetase [Source:RGD Symbol;Acc:621167] |
| Ensembl ID | ENSRNOG00000003743 |
| Bio databases IDs | |
| Aliases | aspartyl-tRNA synthetase |
| Synonyms | 5730439G15Rik, aspartyl-tRNA synthetase 1, aspRS, DARS, DRS1, HBSL |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dars often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- class_II_aaRS-like_core
- OB-fold nucleic acid binding domain
- aminoacylase
- tRNA synthetases class II (D, K and N)
- enzyme
- protein binding
- aspartate-tRNA ligase
- asparaginyl-tRNA synthetase
- nondiscriminating aspartyl-tRNA synthetase
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- cyclin A
- ERK1/2
- CREB
- ELK1
- protein-protein complex
disease
- neoplasia
- organismal death
- hypomyelination with brainstem and spinal cord involvement and leg spasticity
- systemic lupus erythematosus
role in cell
- growth
- translation in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dars gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- aspartyl-tRNA aminoacylation
- translation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- aminoacyl-tRNA synthetase multienzyme complex
- synapse
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA binding
- aspartate-tRNA ligase activity
- aminoacylase activity