Dars Gene Summary [Mouse]
Predicted to enable RNA binding activity and aspartate-tRNA ligase activity. Predicted to be involved in aspartyl-tRNA aminoacylation. Located in cytoplasm and synapse. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human DARS1 (aspartyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dars |
| Official Name | aspartyl-tRNA synthetase [Source:MGI Symbol;Acc:MGI:2442544] |
| Ensembl ID | ENSMUSG00000026356 |
| Bio databases IDs | |
| Aliases | aspartyl-tRNA synthetase |
| Synonyms | 5730439G15Rik, aspartyl-tRNA synthetase 1, aspRS, DARS, DRS1, HBSL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dars often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- class_II_aaRS-like_core
- OB-fold nucleic acid binding domain
- aminoacylase
- tRNA synthetases class II (D, K and N)
- enzyme
- protein binding
- aspartate-tRNA ligase
- asparaginyl-tRNA synthetase
- nondiscriminating aspartyl-tRNA synthetase
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- cyclin A
- ERK1/2
- CREB
- ELK1
- protein-protein complex
disease
- neoplasia
- organismal death
- hypomyelination with brainstem and spinal cord involvement and leg spasticity
- systemic lupus erythematosus
phenotypes
- decreased prepulse inhibition
- embryonic growth retardation
- embryonic lethality during organogenesis complete penetrance
role in cell
- growth
- translation in
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- cytosol
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dars gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- aspartyl-tRNA aminoacylation
- translation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- cytosol
- aminoacyl-tRNA synthetase multienzyme complex
- synapse
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- RNA binding
- aspartate-tRNA ligase activity
- aminoacylase activity