Galc Gene Summary [Rat]
Predicted to enable galactosylceramidase activity. Predicted to be involved in galactosylceramide catabolic process. Predicted to act upstream of or within myelination. Predicted to be located in membrane. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in Krabbe disease. Orthologous to human GALC (galactosylceramidase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Galc |
| Official Name | galactosylceramidase [Source:RGD Symbol;Acc:1359384] |
| Ensembl ID | ENSRNOG00000003759 |
| Bio databases IDs | |
| Aliases | galactosylceramidase |
| Synonyms | 2310068B06Rik, A930008M05Rik, Gacy, galactosylceramidase, twi, twitcher |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Galc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- galactosylceramidase
- Glycosyl hydrolase family 30 TIM-barrel domain
- enzyme
- Glycosyl hydrolase family 59
- Glycosyl hydrolase family 59 central domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- galactosylceramide beta-galactosidase deficiency
- inflammatory bowel disease
- Parkinson disease
- Crohn disease
- hereditary disorder
- metabolic syndrome X
- Fabry disease
- systemic lupus erythematosus
- multiple sclerosis
role in cell
- expression in
- replication in
- accumulation in
- myelination
- rearrangement
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
- Golgi Apparatus
- lysosomal compartment
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Galc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycosphingolipid catabolic process
- myelination
- galactosylceramide catabolic process
Cellular Component
Where in the cell the gene product is active
- lysosomal lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- galactosylceramidase activity