Osbp Gene Summary [Rat]
Predicted to enable several functions, including phosphatidylinositol-4-phosphate binding activity; sterol binding activity; and sterol transfer activity. Involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of protein modification process; and positive regulation of secretory granule organization. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be active in cytosol; perinuclear endoplasmic reticulum; and plasma membrane. Orthologous to human OSBP (oxysterol binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Osbp |
| Official Name | oxysterol binding protein [Source:RGD Symbol;Acc:1308069] |
| Ensembl ID | ENSRNOG00000021057 |
| Bio databases IDs | |
| Aliases | oxysterol binding protein |
| Synonyms | 1110018F06RIK, mKIAA4220, OSBP1, oxysterol binding protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Osbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- oxysterol binding
- OSBP-related domain
- PH domain
- protein domain specific binding
- protein binding
- Pleckstrin homology-like domain
- Oxysterol-binding protein
- phosphatidylinositol binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- perinuclear region
- cellular membrane
- Golgi Apparatus
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- trans Golgi network
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Osbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sterol transport
- intracellular cholesterol transport
- phospholipid transport
- positive regulation of tyrosine phosphorylation of STAT protein
- ceramide transport
- bile acid biosynthetic process
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- sphingomyelin biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
- nucleolus
- plasma membrane
- nucleoplasm
- endoplasmic reticulum membrane
- trans-Golgi network
- perinuclear region of cytoplasm
- perinuclear endoplasmic reticulum
- cytoplasm
- membrane
- cell junction
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- protein domain specific binding
- sterol binding
- protein binding
- oxysterol binding