Ppfibp1 Gene Summary [Rat]
Predicted to be involved in cortical microtubule organization and neuromuscular junction development. Predicted to be located in cell cortex and plasma membrane. Predicted to be active in presynaptic active zone. Orthologous to human PPFIBP1 (PPFIA binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppfibp1 |
| Official Name | PPFIA binding protein 1 [Source:RGD Symbol;Acc:1310010] |
| Ensembl ID | ENSRNOG00000031709 |
| Bio databases IDs | |
| Aliases | PPFIA binding protein 1 |
| Synonyms | 4632409B19Rik, hSGT2, hSgt2p, L2, Liprin beta 1, Liprin β 1, NEDSMBA, PPFIA binding protein 1, PTPRF interacting protein, binding protein 1 (liprin beta 1), PTPRF interacting protein, binding protein 1 (liprin β 1), SGT2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppfibp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cortexillin I, coiled coil
- Nuf2, DHR10-like domain
- Autophagy protein 16 (ATG16)
- Ezrin/radixin/moesin, alpha-helical domain
- SAM (Sterile alpha motif )
- Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins
- SAM domain
- Rabaptin
- coiled-coil domain
- protein binding
- Sterile alpha motif
- SAM domain (Sterile alpha motif)
- Growth-arrest specific micro-tubule binding
- liprin homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- perinuclear region
- cell cortex
- cytosol
- plasma membrane projections
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppfibp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuromuscular junction development
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone
- focal adhesion
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding