Tdp1 Gene Summary [Rat]
Predicted to enable 3'-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair. Predicted to act upstream of or within single strand break repair. Predicted to be located in cytoplasm; nucleoplasm; and plasma membrane. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia with axonal neuropathy 1. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tdp1 |
| Official Name | tyrosyl-DNA phosphodiesterase 1 [Source:RGD Symbol;Acc:1309618] |
| Ensembl ID | ENSRNOG00000003831 |
| Bio databases IDs | |
| Aliases | tyrosyl-DNA phosphodiesterase 1 |
| Synonyms | 2810481F14RIK, 4921509N21Rik, AW493413, E430034L06Rik, Gm40556, MLZ-501, SCAN1, tyrosyl-DNA phosphodiesterase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tdp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphodiesterase I
- Tyrosyl-DNA phosphodiesterase
- single-stranded DNA binding
- double-stranded DNA binding
- tyrosyl-DNA phosophodiesterase
- enzyme
- protein binding
- Catalytic domain of phospholipase D superfamily proteins
Pathways
Biological processes and signaling networks where the Tdp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uveal melanoma
- ocular melanoma
- chromosomal instability
- Dukes stage C colorectal cancer
- autosomal recessive spinocerebellar ataxia with axonal neuropathy type 1
- choroidal melanoma
- epithelioid uveal melanoma
- epithelioid melanoma cancer
regulates
- DNA adduct
role in cell
- cell viability
- colony formation by
- cell proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- Plasma Membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tdp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- single strand break repair
- DNA repair
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- exonuclease activity
- double-stranded DNA binding
- 3'-tyrosyl-DNA phosphodiesterase activity
- single-stranded DNA binding