Banf1 Gene Summary [Rat]
Enables identical protein binding activity. Predicted to be involved in several processes, including negative regulation of type I interferon production; negative regulation of viral genome replication; and regulation of innate immune response. Predicted to act upstream of or within DNA integration. Located in condensed chromosome. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Nestor-Guillermo progeria syndrome. Orthologous to human BANF1 (barrier to autointegration nuclear assembly factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Banf1 |
| Official Name | barrier to autointegration factor 1 [Source:RGD Symbol;Acc:620662] |
| Ensembl ID | ENSRNOG00000020460 |
| Bio databases IDs | |
| Aliases | barrier to autointegration factor 1 |
| Synonyms | BAF, BAF nuclear assembly factor 1, barrier to autointegration nuclear assembly factor 1, BCRG1, BCRP1, C78287, D14S1460, L2bp1, L2bp1/Baf, NGPS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Banf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Barrier to autointegration factor
- double-stranded DNA binding
- protein homodimerization
- protein binding
- identical protein binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Nestor-Guillermo progeria syndrome
- aortic valve calcification
- gastric cancer
role in cell
- expression in
- replication in
- phosphorylation in
- integrity
- production in
- survival
- cell cycle progression
- binding in
- invagination in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
- chromosome
- inner nuclear membrane
- nucleoplasm
- nuclear envelope
- photoreceptor outer segments
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Banf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic nuclear envelope reassembly
- response to oxidative stress
- negative regulation of type I interferon production
- chromosome organization
- negative regulation of protein ADP-ribosylation
- DNA integration
- response to virus
- chromatin organization
- negative regulation of viral genome replication
- negative regulation of innate immune response
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- condensed chromosome
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- protein homodimerization activity
- double-stranded DNA binding