Cltrn Gene Summary [Rat]
Predicted to enable protein homodimerization activity. Predicted to be involved in SNARE complex assembly; positive regulation of L-proline import across plasma membrane; and regulation of transmembrane transporter activity. Predicted to act upstream of with a positive effect on calcium-ion regulated exocytosis and insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in brush border membrane and cytoplasm. Predicted to be active in plasma membrane. Orthologous to human CLTRN (collectrin, amino acid transport regulator). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cltrn |
| Official Name | collectrin, amino acid transport regulator [Source:RGD Symbol;Acc:708489] |
| Ensembl ID | ENSRNOG00000003960 |
| Bio databases IDs | |
| Aliases | collectrin, amino acid transport regulator |
| Synonyms | 0610008J07Rik, collectrin, collectrin, amino acid transport regulator, NX-17, TMEM27 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cltrn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- protein binding
- Renal amino acid transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- polyuria
- bronchiolo-alveolar adenocarcinoma
- broncho-alveolar lung cancer
- hepatocellular carcinoma
- liver cancer
- COVID-19
- hyperphagia
- crystalluria
- aminoaciduria
role in cell
- expression in
- function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- apical membrane
- basolateral membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cltrn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin secretion involved in cellular response to glucose stimulus
- SNARE complex assembly
- regulation of transmembrane transporter activity
- calcium ion-dependent exocytosis
- positive regulation of amino acid transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- brush border membrane
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity