Scnn1a

Enables WW domain binding activity; actin binding activity; and ligand-gated sodium channel activity. Contributes to sodium ion transmembrane transporter activity. Involved in intracellular sodium ion homeostasis; regulation of body fluid levels; and sodium ion import across plasma membrane. Located in several cellular components, including acrosomal vesicle; apical plasma membrane; and sperm principal piece. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 2; and pseudohypoaldosteronism. Orthologous to human SCNN1A (sodium channel epithelial 1 subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scnn1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Scnn1a gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Scnn1a gene, providing context for its role in the cell.