Vamp2 Gene Summary [Rat]
Enables several functions, including calcium-dependent protein binding activity; syntaxin-1 binding activity; and transmembrane transporter binding activity. Involved in several processes, including SNARE complex assembly; regulation of delayed rectifier potassium channel activity; and synaptic vesicle exocytosis. Located in neuron projection terminus; plasma membrane; and secretory vesicle. Part of several cellular components, including synaptobrevin 2-SNAP-25-syntaxin-1a complex; synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex; and synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in postsynaptic cytosol; postsynaptic density; and synaptic vesicle membrane. Orthologous to human VAMP2 (vesicle associated membrane protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vamp2 |
| Official Name | vesicle-associated membrane protein 2 [Source:RGD Symbol;Acc:3949] |
| Ensembl ID | ENSRNOG00000006989 |
| Bio databases IDs | |
| Aliases | vesicle-associated membrane protein 2 |
| Synonyms | mVam2, NEDHAHM, RATVAMPB, RATVAMPIR, SYB, SYB2, sybII, Synaptobrevin 2, Vamp ii, vesicle-associated membrane protein 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vamp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- phospholipid binding
- calcium-dependent protein binding
- lipid binding
- calmodulin binding
- calmodulin binding domain
- coiled-coil domain
- protein binding
- identical protein binding
- Synaptobrevin
- syntaxin binding
- myosin binding
- binding protein
- botulin neurotoxin cleavage site
- cytoplasmic domain
- syntaxin-1 binding
- lumenal domain
- transmembrane domain
- ion channel binding
- dnSNARE domain
- cytosolic tail domain
- SNARE motif
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Vamp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- low back pain
- stroke
- seizures
- COVID-19
- multiple sclerosis
- neurodevelopmental disorder with hypotonia and autistic features with hyperkinetic movements
- growth failure
- behavioral deficit
- neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements
- cervical dystonia
regulates
- REN
- insulin
- INS
- adenosine triphosphate
- lipid
- L-glutamic acid
- NMDA receptor
- neurotransmitter
- SNARE
- renin
role in cell
- expression in
- cell death
- growth
- quantity
- fusion
- size
- density
- loss in
- transmission
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- intracellular membrane fractions
- synaptic plasma membrane fractions
- low-density microsomal fraction
- primary granule fractions
- detergent-soluble membrane fractions
- membrane fraction
- synaptic vesicle membrane
- glutaminergic synapse
- endocytic vesicle membrane
- cytoplasmic vesicle membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- synaptic cleft
- perinuclear region
- intracellular membranes
- cellular membrane
- vacuole
- vesicles
- secretory granule membrane
- granules
- cytosol
- vesicle membrane
- apical membrane
- trans Golgi network
- endosomal compartment
- zymogen granules
- synaptic vesicles
- neurites
- nerve ending
- synaptosomes
- synapse
- rod spherules
- recycling endosomes
- early endosomes
- transport vesicles
- cytoplasmic vesicles
- secretory vesicles
- synaptic-like microvesicles
- specific granules
- tertiary granules
- storage granules
- secretory granules
- membrane rafts
- membrane processes
- perikaryon
- axons
- postsynaptic density
- presynaptic terminals
- clathrin-coated vesicles
- immature secretory granules
- mature secretory granules
- perinuclear recycling endosome
- detergent-soluble fraction
- synaptic vesicle fractions
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vamp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intracellular protein transport
- membrane fusion
- eosinophil degranulation
- macromolecular complex assembly
- SNARE complex assembly
- protein transport
- Golgi to plasma membrane protein transport
- natural killer cell degranulation
- neutrophil degranulation
- regulation of vesicle-mediated transport
- exocytosis
- cellular response to insulin stimulus
- response to glucose stimulus
- vesicle-mediated transport
- mucus secretion
- vesicle fusion
- synaptic vesicle endocytosis
- long-term synaptic potentiation
- calcium ion-dependent exocytosis
- regulation of exocytosis
- synaptic vesicle exocytosis
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- synapse
- neuron projection
- clathrin sculpted glutamate transport vesicle membrane
- secretory granule membrane
- clathrin sculpted monoamine transport vesicle membrane
- trans-Golgi network
- clathrin-coated endocytic vesicle membrane
- intracellular membrane-bounded organelle
- synaptobrevin 2-SNAP-25-syntaxin-1a complex
- cytosol
- cytoplasmic vesicle
- clathrin sculpted gamma-aminobutyric acid transport vesicle membrane
- voltage-gated potassium channel complex
- secretory granule
- plasma membrane
- zymogen granule membrane
- neuron projection terminus
- perinuclear region of cytoplasm
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
- membrane
- vesicle
- SNARE complex
- synaptic vesicle membrane
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- syntaxin binding
- syntaxin-1 binding
- SNAP receptor activity
- calcium-dependent protein binding
- SNARE binding
- phospholipid binding