Slc6a19 Gene Summary [Rat]
Predicted to enable neutral L-amino acid transmembrane transporter activity. Involved in response to nutrient. Predicted to be active in apical plasma membrane and brush border membrane. Biomarker of hypertension. Human ortholog(s) of this gene implicated in Hartnup disease. Orthologous to human SLC6A19 (solute carrier family 6 member 19). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc6a19 |
| Official Name | solute carrier family 6 member 19 [Source:RGD Symbol;Acc:1594328] |
| Ensembl ID | ENSRNOG00000026501 |
| Bio databases IDs | |
| Aliases | solute carrier family 6 member 19 |
| Synonyms | 4632401C08Rik, B0AT1, HND, LOC100128907, LOC340024, solute carrier family 6 member 19, solute carrier family 6 (neurotransmitter transporter), member 19 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc6a19 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium:neurotransmitter symporter family
- protein binding
- Solute carrier families 5 and 6-like; solute binding domain
- amino acid transporter
- transporter
- neutral amino acid transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- weight loss
- diabetes mellitus
- Hartnup disorder
- colorectal cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- aminoaciduria
- kidney carcinoma
- renal cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- brush border
- podocyte slit diaphragm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc6a19 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral infectious cycle
- neutral amino acid transport
- response to nutrient
- sodium ion transmembrane transport
- amino acid transport
- amino acid transmembrane transport
Cellular Component
Where in the cell the gene product is active
- brush border membrane
- extracellular vesicular exosome
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- neutral amino acid transmembrane transporter activity
- symporter activity
- amino acid transmembrane transporter activity