Pfkfb2 Gene Summary [Rat]
Enables fructose-2,6-bisphosphate 2-phosphatase activity and kinase binding activity. Involved in several processes, including monocarboxylic acid biosynthetic process; positive regulation of glucokinase activity; and positive regulation of insulin secretion. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pfkfb2 |
| Official Name | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [Source:RGD Symbol;Acc:3309] |
| Ensembl ID | ENSRNOG00000004162 |
| Bio databases IDs | |
| Aliases | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 |
| Synonyms | 4930568D07Rik, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2, LOC107984109, PFK-2, PFK-2/FBPase-2, RH2K |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pfkfb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase binding
- protein kinase binding
- Histidine phosphatase superfamily (branch 1)
- NK
- Phosphoglycerate mutase family
- fructose-2,6-bisphosphate 2-phosphatase
- enzyme
- alpha-ribazole phosphatase
- Histidine phosphatase domain
- protein binding
- 6-phosphofructo-2-kinase
- AAA domain
Pathways
Biological processes and signaling networks where the Pfkfb2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hepatocellular carcinoma
- septic shock
- glaucoma
- schizophrenia
- polycystic kidney disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- chronic lymphocytic leukemia
regulated by
- p38 MAPK
- LY294002
- dexamethasone
- AKT
- PX 478
- wortmannin
- mir-1252
- metribolone
- torin1
- sirolimus
role in cell
- proliferation
- production in
- migration
- survival
- invasion by
- glycolysis in
- signaling in
- lipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pfkfb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to glucose stimulus
- glycolysis
- fructose 2,6-bisphosphate metabolic process
- fructose metabolic process
- lactate metabolic process
- positive regulation of insulin secretion
- carbohydrate phosphorylation
- glucose catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein binding
- fructose-2,6-bisphosphate 2-phosphatase activity
- 6-phosphofructo-2-kinase activity