Gck Gene Summary [Rat]
Enables several functions, including D-glucose binding activity; adenyl ribonucleotide binding activity; and hexokinase activity. Involved in several processes, including hexose metabolic process; positive regulation of phosphate metabolic process; and regulation of secretion by cell. Located in several cellular components, including actin filament; basal cortex; and secretory granule. Used to study obesity; steatotic liver disease; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple) and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gck |
| Official Name | glucokinase [Source:RGD Symbol;Acc:2670] |
| Ensembl ID | ENSRNOG00000061527 |
| Bio databases IDs | |
| Aliases | glucokinase |
| Synonyms | FGQTL3, GCK (MODY2), GK, GLK, Gls006, glucokinase, GLUKA, HHF3, HK4, HKIV, Hlb62, HXKP, Lgk, LGLK, MODY2, Pgk, PNDM1, RNGK2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gck often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- catalytic domain
- ADP binding
- protein phosphatase binding
- ATP binding
- glucose binding
- PLN02914
- glucokinase
- enzyme
- fructokinase
- protein binding
- magnesium ion binding
- kinase
- PEST domain
- mannokinase
- hexokinase
- C-terminal extension
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Gck gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- monogenic diabetes
- maturity onset diabetes of the young type 2
- maturity-onset diabetes of the young
- developmental delay, epilepsy, and neonatal diabetes syndrome
- metabolic syndrome X
- hyperglycemia
- diabetes mellitus
- obesity
- coronary artery disease
role in cell
- expression in
- apoptosis
- response by
- glycolysis in
- response in
- gluconeogenesis in
- function
- nitrosylation in
- excitation
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- Mitochondria
- actin filaments
- cytosol
- nucleoplasm
- secretory granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gck gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion import
- glycolysis
- regulation of potassium ion transport
- negative regulation of gluconeogenesis
- regulation of glycolysis
- glucose metabolic process
- carbohydrate phosphorylation
- glucose catabolic process
- positive regulation of glycogen biosynthetic process
- cellular response to insulin stimulus
- regulation of insulin secretion
- glucose 6-phosphate metabolic process
- response to glucose stimulus
- cellular glucose homeostasis
- cellular response to leptin stimulus
- glucose homeostasis
- NADP metabolic process
- positive regulation of insulin secretion
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- glucose binding
- ATP binding
- protein binding
- glucokinase activity
- mannokinase activity
- fructokinase activity