TAC3 Gene Summary [Human]
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | TAC3 |
| Official Name | tachykinin precursor 3 [Source:HGNC Symbol;Acc:HGNC:11521] |
| Ensembl ID | ENSG00000166863 |
| Bio databases IDs | |
| Aliases | tachykinin precursor 3, preprotachykinin-B |
| Synonyms | HH10, LncZBTB39, NEUROKININ B, Neurokinin Beta, Neurokinin β, NK3, NKB, NKKB, NKNB, PPT-B, PRO1155, Tac2, tachykinin 2, Tachykinin B, tachykinin precursor 3, ZNEUROK1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- coiled-coil domain
- Neurokinin B
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Kallmann syndrome type 10
- infertility condition
- hot flashes
- amnesia
- delayed puberty
- early-onset preeclampsia
- hypogonadotropic hypogonadism 7
- hypogonadotropic hypogonadism 10 without anosmia
role in cell
- proliferation
- firing
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- cell surface
- Plasma Membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- female pregnancy
- tachykinin receptor signaling pathway
- positive regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding