Tacr2 Gene Summary [Rat]
Enables substance K receptor activity. Involved in several processes, including operant conditioning; positive regulation of uterine smooth muscle contraction; and regulation of secretion by cell. Predicted to be located in sperm flagellum and sperm head. Predicted to be active in plasma membrane and sperm midpiece. Used to study colitis and pulmonary hypertension. Biomarker of colitis. Human ortholog(s) of this gene implicated in asthma. Orthologous to human TACR2 (tachykinin receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tacr2 |
| Official Name | tachykinin receptor 2 [Source:RGD Symbol;Acc:3812] |
| Ensembl ID | ENSRNOG00000050658 |
| Bio databases IDs | |
| Aliases | tachykinin receptor 2 |
| Synonyms | NEUROKININ-2 receptor, NK2R, NK2 receptor, NKNAR, SKR, TAC2R, tachykinin receptor 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tacr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- tachykinin receptor
- Cholecystokinin A receptor, N-terminal
- substance K receptor
- alpha helix
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Tacr2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- major depression
- organismal death
- uterine serous papillary cancer
- breast carcinoma
role in cell
- expression in
- phosphorylation in
- autophagy in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- sperm midpiece
- sperm tail
- sperm head
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tacr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of acetylcholine secretion
- tachykinin receptor signaling pathway
- positive regulation of smooth muscle contraction
- positive regulation of vascular permeability
- positive regulation of ion transport
- positive regulation of uterine smooth muscle contraction
- muscle contraction
- intestine smooth muscle contraction
- negative regulation of luteinizing hormone secretion
- response to electrical stimulus
- prolactin secretion
- operant conditioning
Cellular Component
Where in the cell the gene product is active
- sperm midpiece
- sperm flagellum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- substance K receptor activity
- tachykinin receptor activity