Tac2 Gene Summary [Mouse]
This gene encodes a member of the tachykinin family of signaling peptides that is widely expressed in the central nervous system and plays a role in diverse processes such as water homeostasis, pulmonary inflammation, cognition, fear memory consolidation and preeclampsia. The encoded protein is enzymatically processed to generate the mature neuropeptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | Tac2 |
| Official Name | tachykinin 2 [Source:MGI Symbol;Acc:MGI:98476] |
| Ensembl ID | ENSMUSG00000025400 |
| Bio databases IDs | |
| Aliases | tachykinin 2 |
| Synonyms | HH10, LncZBTB39, NEUROKININ B, Neurokinin Beta, Neurokinin β, NK3, NKB, NKKB, NKNB, PPT-B, PRO1155, Tac2, tachykinin 2, Tachykinin B, tachykinin precursor 3, ZNEUROK1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tac2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein-coupled receptor binding
- coiled-coil domain
- Neurokinin B
- protein binding
- receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Kallmann syndrome type 10
- infertility condition
- hot flashes
- amnesia
- delayed puberty
- early-onset preeclampsia
- hypogonadotropic hypogonadism 7
- hypogonadotropic hypogonadism 10 without anosmia
regulated by
- Influenza A virus (A/Puerto Rico/8/34(H1N1))
- ESR1
- beta-estradiol
- cisplatin
- estradiol-17beta-benzoate
- erythroid cells
- Ca2+
- testosterone
- dihydrotestosterone
- estrogen
role in cell
- proliferation
- firing
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- cell surface
- Plasma Membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tac2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- female pregnancy
- tachykinin receptor signaling pathway
- positive regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding