Ubr1 Gene Summary [Rat]
Predicted to enable L-leucine binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to L-leucine; negative regulation of TOR signaling; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome complex and ubiquitin ligase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Johanson-Blizzard syndrome and cardiovascular system disease. Orthologous to human UBR1 (ubiquitin protein ligase E3 component n-recognin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ubr1 |
| Official Name | ubiquitin protein ligase E3 component n-recognin 1 [Source:RGD Symbol;Acc:1562326] |
| Ensembl ID | ENSRNOG00000037207 |
| Bio databases IDs | |
| Aliases | ubiquitin protein ligase E3 component n-recognin 1 |
| Synonyms | AI504731, E3 Alpha, E3 α, JBS, RGD1562326, ubiquitin protein ligase E3 component n-recognin 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ubr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative zinc finger in N-recognin (UBR box)
- Putative zinc finger in N-recognin
- binding protein
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- UBR-box
- enzyme
- protein binding
- Proteolysis_6 C-terminal
- ATP-dependent Clp protease adaptor protein ClpS
- amino acid binding
Pathways
Biological processes and signaling networks where the Ubr1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- Johanson-Blizzard syndrome
- hypoalbuminemia
- hypertension
- bleeding
- hereditary disorder
- lymphomagenesis
- B cell cancer
- B-cell neoplasia
- hematologic cancer
role in cell
- differentiation
- apoptosis
- expression in
- response by
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ubr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- cellular response to leucine
- ubiquitin-dependent protein catabolic process via the N-end rule pathway
- negative regulation of TOR signaling cascade
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- cytoplasm
- cytosol
- proteasome complex
Molecular Function
What the gene product does at the molecular level
- leucine binding
- zinc ion binding
- protein binding