Ppfia2 Gene Summary [Rat]
A structural constituent of postsynaptic density and structural constituent of presynapse. Involved in regulation of synaptic vesicle exocytosis. Is active in several cellular components, including postsynaptic density; presynaptic membrane; and synaptic vesicle. Orthologous to human PPFIA2 (PTPRF interacting protein alpha 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppfia2 |
| Official Name | PTPRF interacting protein alpha 2 [Source:RGD Symbol;Acc:1305021] |
| Ensembl ID | ENSRNOG00000004353 |
| Bio databases IDs | |
| Aliases | PTPRF interacting protein alpha 2 |
| Synonyms | 5330438O12, B230207K17RIK, E130120L08RIK, Liprin alpha2, mKIAA4112, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), α 2, PTPRF interacting protein alpha 2, PTPRF interacting protein α 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppfia2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ciliary protein causing Leber congenital amaurosis disease
- SAM domain
- coiled-coil domain
- Bin/Amphiphysin/Rvs domain
- Laminin Domain I
- Sterile alpha motif
- SAM domain (Sterile alpha motif)
- Family with sequence similarity 184, A and B
- phosphatase
- liprin homology domain
- SPEC
- Crescentin protein
- RNase Y N-terminal region
- Tropomyosin like
- Ezrin/radixin/moesin, alpha-helical domain
- PspA/IM30 family
- SAM (Sterile alpha motif )
- protein binding
- PLC-beta C terminal
- Domain of unknown function (DUF4659)
- Alpha helical coiled-coil rod protein (HCR)
- Mechanosensitive ion channel porin domain
- RIM-binding protein of the cytomatrix active zone
- binding protein
- Trichohyalin-plectin-homology domain
- Growth-arrest specific micro-tubule binding
- structural molecule
- Domain of unknown function (DUF4472)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- organelle
- Cytoplasm
- cell surface
- cytosol
- presynaptic membrane
- dendritic spines
- synaptic vesicles
- synapse
- neuritic shafts
- ruffled borders
- filopodia
- perikaryon
- axons
- dendrites
- postsynaptic density
- perforated synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppfia2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- regulation of dendritic spine morphogenesis
- synapse organization
- regulation of synaptic vesicle exocytosis
- regulation of dendritic spine development
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- extracellular vesicular exosome
- presynaptic active zone
- cytoplasm
- synaptic vesicle
- dendritic spine
- cytosol
- axon
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding