Ppfia1 Gene Summary [Rat]
Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Located in axon and dendrite. Part of protein-containing complex. Is active in Schaffer collateral - CA1 synapse and spine apparatus. Orthologous to human PPFIA1 (PTPRF interacting protein alpha 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppfia1 |
| Official Name | PTPRF interacting protein alpha 1 [Source:RGD Symbol;Acc:1309009] |
| Ensembl ID | ENSRNOG00000020857 |
| Bio databases IDs | |
| Aliases | PTPRF interacting protein alpha 1 |
| Synonyms | AP002336.5, C030014K08RIK, LIP1, LIP.1, LIPRIN, LIPRIN alpha1, LOC103689951, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), α 1, PTPRF interacting protein alpha 1, PTPRF interacting protein α 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppfia1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- Domain of unknown function (DUF1978)
- RNase Y N-terminal region
- Tropomyosin like
- PspA/IM30 family
- Hyaluronan mediated motility receptor N-terminal
- SAM (Sterile alpha motif )
- coiled-coil domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- Laminin Domain I
- chromosome segregation protein SMC, common bacterial type
- Tropomyosin
- Mechanosensitive ion channel porin domain
- Sterile alpha motif
- SAM domain (Sterile alpha motif)
- phosphatase
- Growth-arrest specific micro-tubule binding
- Apolipoprotein A1/A4/E domain
- Septation ring formation regulator, EzrA
- liprin homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- psoriatic arthritis
- ductal breast carcinoma
- ductal breast cancer
- uterine serous papillary cancer
- androgenic alopecia
regulates
- AMPA receptor
role in cell
- adhesion
- cell spreading
- assembly
- migration
- motility
- invasion by
- dynamics in
- dynamics
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- organelle
- Cytoplasm
- cellular membrane
- focal adhesions
- cell cortex
- cytosol
- growth cone
- synapse
- perikaryon
- axons
- dendrites
- lamellipodia
- synaptosomal fractions
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppfia1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- negative regulation of stress fiber assembly
- synapse organization
- signal transduction
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- presynaptic active zone
- cytoplasm
- cytosol
- macromolecular complex
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding