Kcnj16 Gene Summary [Rat]
Predicted to enable inward rectifier potassium channel activity. Involved in potassium ion transport; regulation of pH; and response to carbon dioxide. Located in basolateral plasma membrane. Used to study hypokalemia and metabolic acidosis. Orthologous to human KCNJ16 (potassium inwardly rectifying channel subfamily J member 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnj16 |
| Official Name | potassium inwardly-rectifying channel, subfamily J, member 16 [Source:RGD Symbol;Acc:61824] |
| Ensembl ID | ENSRNOG00000004713 |
| Bio databases IDs | |
| Aliases | potassium inwardly-rectifying channel, subfamily J, member 16 |
| Synonyms | 6430410F18Rik, BIR9, HKTD, KIR5.1, Knkj16, potassium inwardly rectifying channel subfamily J member 16, potassium inwardly-rectifying channel, subfamily J, member 16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnj16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- inward rectifier potassium channel
- Inward rectifier potassium channel C-terminal domain
- Inward rectifier potassium channel transmembrane domain
- protein binding
- ion channel
Pathways
Biological processes and signaling networks where the Kcnj16 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypokalemic tubulopathy and deafness
- familial hypokalemic alkalosis with specific renal tubulopathy
- Wilms tumor
- Wilms tumorigenesis
- diabetic nephropathy
- periodontitis
regulates
- K+
role in cell
- growth
- response
- function
- response by
- pH
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- somatodendritic region
- cellular membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnj16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- regulation of ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- inward rectifier potassium channel activity